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Medical Coverage Policy: 0266
Hormonal Therapy
For both adults and adolescents, hormonal treatment for gender dysphoria must be administered
and monitored by a qualified healthcare practitioner as therapy requires ongoing medical
management, including physical examination and laboratory studies to manage dosage, side
effects, etc. Lifelong maintenance is usually required.
Adults: Prior to and following gender reassignment surgery, individuals may undergo hormone
replacement therapy. Biological males (i.e., assigned male at birth) are treated with estrogens and
anti-androgens to increase breast size, redistribute body fat, soften skin, decrease body hair, and
decrease testicular size and erections. Biological females (i.e., assigned female at birth) are
treated with androgens such as testosterone to deepen voice, increase muscle and bone mass,
decrease breast size, increase clitoris size, and increase facial and body hair. For some individuals
hormone replacement therapy (HRT) may be effective in reducing the adverse psychologic impact
of gender dysphoria. Hormone therapy is usually initiated upon referral from a qualified mental
health professional or a health professional competent in behavioral health and gender dysphoria
treatment specifically.
Adolescents: Adolescence is generally defined as the time between puberty and reaching the age
of majority (WPATH 8, 2022), an individual age 10 to 19 years (World Health Organization) or
until reaching age 21 years (American Academy of Pediatrics [AAP]). For some adolescents the
onset of puberty may worsen gender dysphoria. For these individuals puberty-suppressing
hormones (e.g., GnRH analogues) may be provided to individuals who have reached at least
Tanner stage 2 of sexual development (Hembree, et al., 2017; WPATH, 2022). Consistent with
adult hormone therapy, treatment of adolescents involves a multidisciplinary team, however when
treating an adolescent, a pediatric endocrinologist should be included as a part of the team. Pre-
pubertal hormone suppression differs from hormone therapy used in adults and may not be
without consequence; some pharmaceutical agents may cause negative physical side effects (e.g.,
height, bone growth).
Gender Reassignment Surgery
The term "gender reassignment surgery," also known as gender affirmation surgery, sexual
reassignment surgery, or gender confirming surgery may be part of a treatment plan for gender
dysphoria. The terms may be used to refer to either the reconstruction of male or female genitalia
specifically, or the reshaping by any surgical procedure of a male body into a body with female
appearance, or vice versa for an individual to function socially in the role to which they identify.
Such procedures that tend to display outward appearance generally include facial procedures,
chest reconstructive procedures as well as some genital reconstructive procedures (e.g.,
phalloplasty).
Performing gender reassignment surgery prior to age 18, or the legal age to give consent, is not
recommended by most professional societies (American College of Obstetricians and Gynecology
[ACOG], 2017; American Psychiatric Association (APA), 2012, Endocrine Society, 2017). Gender
reassignment surgery is intended to be a permanent change (non-reversible), establishing
congruency between an individual’s gender identity and physical appearance. Therefore, a careful
and accurate diagnosis is essential for treatment and can be made only as part of a long-term
diagnostic process involving a multidisciplinary specialty approach that includes an extensive case
history; gynecological, endocrine, and urological examination; and a clinical
psychiatric/psychological examination. Individuals who choose to undergo gender reassignment
surgery must be fully informed regarding treatment options with confirmation from the mental
health professional that the individual is considered a candidate for surgical treatment.